AMB | Accelerated Muscle Biotechnologies

AMB co-founder Anthony Hessel inside the LiX beamline hutch.

Our Services

AMB provides comprehensive services for muscle X-ray diffraction and muscle fiber Experimentations.

View Muscle X-ray Diffraction

View Muscle Fiber Experimentation

Location: LiX beamline, NSLS-II. USA

Schematic conceptually showing the positioning of a muscle fiber on a synchrotron beamline with a force transducer and length motor to run simultaneous mechanics experiments.

Work loop trajectories can be measured simultaneously with X-ray diffraction to correlate mechanics with sarcomeric protein organization

Sarcomeric protein organization in the from of actomyosin lattice spacing, actin strains, and myosin strains can all be directly measured using X-ray diffraction.

Muscle X-Ray Diffraction

Tailored made experimental design and preparation

Initial project objective refinement and experimental design strategy and feasibility
Determination and preparation of necessary wet lab equipment
Design, fabrication, and installation of muscle and X-ray systems to optimize data acquisition and quality.

Customized data analysis
and interpretation

High-throughput processing and statistical analysis of diffraction or mechanical testing data acquired either by us or others using semi-automated in-house code base.

Commitment to trainees

AMB is committed to training the next generation of scientists from diverse backgrounds, especially since there is a shortage of qualified X-ray scientists worldwide. Therefore, AMB will help train students / trainees in X-ray theory, practical application during experimental collection, and analysis/interpretation as time permits.

Muscle Fiber Experimentation

Career muscle scientists and engineers available to consult, support, or directly run muscle research programs

In our laboratories, we carry out many of the most important muscle fiber experiments for our clients and collaboration partners and indeed support our staff scientists to continue their own personal research interests.

Mechanics experiments for permeabilized cardiac and skeletal muscle up to biosafety level S2

We offer both one-stop and piecewise solutions for muscle mechanics experiments from flash frozen or glycerol permeabilized muscle tissue.

Biochemistry

Protein gels, protein raising and purification are also available depending on research needs. Confocal experimentation is also possible.

Ground-up building of muscle mechanics rigs

In collaboration with Aurora Scientific, we assist newly established muscle labs with designing experimental rigs and choosing appropriate equipment for high-fidelity muscle mechanics experiments based on muscle types and research needs.

Training Services

We offer custom training programs to train new staff in preparing muscle fibers and run their own mechanics set up. Both onsite training at your location or at our facilities in Hamburg, Germany are available options.